神经节苷脂治疗急性颅脑外伤临床观察

Clinical Use of Ganglioside in Acute Head Trauma

目的观察神经节苷脂对急性颅脑损伤患者的疗效。方法将急性脑外伤患者随机分为神经节苷脂组(60例)和胞磷胆碱治疗组(60例),观察患者治疗后GOS的变化。结果与胞磷胆碱治疗相比,神经节苷脂对中、重型颅脑损伤、硬膜下血肿和脑内血肿的治疗效果更好,均显著高于对照组(P<0.05)。结论神经节苷脂应用于急性颅脑损伤患者时能减轻脑水肿,促进脑功能恢复,降低死亡率,改善预后。

Objective To analyze the effects of ganglioside on acute head trauma. Methods A total of 120 patients with acute raumatic head injury were divided randomly into two groups （60 each in ganglioside group and control group）. The clinical data, neurological outcome after treatment were observed. Results Ganglioside was superior to citicoline in the treatment of moderate and severe brain injuries, especially for subdural hematoma and intracerebral hematoma （P 0.05）. Conclusion A successive early large dosage of ganglioside can relieve traumatic brain edema, improve the recovery of coma and reduce the disability in acute severe brain injuries.