碱性离子液体[bmim]OH促进一锅串联合成七元硫杂环化合物

A Facile and Efficient One-Pot Synthesis of Seven-Membered Sulfur Heterocyclic Compounds Using OH as Catalyst and Solvent

碱性离子液体[bmim]OH能快速、高选择性地催化有机硫试剂与丙烯酸乙烯酯之间的直链加成反应.通过这种方法,合成了12种β-烷基硫取代的丙酸乙烯酯类含硫化合物.进一步调控反应温度和时间可以实现Michael加成和分子内的加成-消除反应的一锅串联成环反应.利用碱性离子液体[bmim]OH选择性促进巯基亲核性的策略,成功地合成了6种七元硫杂环化合物,对产物进行了表征确定.

A rapid method for the straight chain addition of thiols to vinyl acrylates was developed by using basic ionic liquid OH as catalyst and solvent.The basic ionic liquid used as catalyst for the cascade reaction of Michael addition and intramolecular addition-elimination reaction in one pot was applied to syn-thesize a series of sulfur heterocycles bearing lactone or lactam functional groups.In this paper,18 com-pounds were synthesized including 12 Michael adducts and 6 sulfur heterocycles.These compounds were characterized by 1H NMR and 13C NMR spectra.