N-[3-(4-喹唑啉基)氨基-1H-吡唑-4-甲酰基]醛腙类衍生物的合成及抗菌活性研究

Synthesis and Fungicidal Activities of N-[(3-(4-Quinazolinyl)amino-1H-pyrazole-4-formyl)aldehyde Hydrazones

以4-氯喹唑啉、3-氨基-4-吡唑甲酸乙酯和芳醛为原料,合成了13个新型的N-[3-(4-喹唑啉基)氨基-1H-吡唑-4-甲酰基]醛腙类化合物,通过IR,1H NMR,13C NMR和元素分析对其结构进行了确认.初步生物活性测试结果表明,在50μg/mL浓度下,化合物5d对小麦赤霉菌和苹果腐烂菌的抑制率与对照药剂噁霉灵相当;化合物5k对小麦赤霉菌的抑制率则高于噁霉灵.

Using 4-chloroquinazoline,ethyl 3-amino-4-pyrazolecarboxylate and aromatic aldehyde as starting compounds,thirteen novel N-[（3-（4-quinazolinyl）amino-1H-pyrazole-4-formyl]aldehyde hydrazones were synthesized.Their structures were confirmed by IR,1H NMR,13C NMR spectra and elemental analy-sis.Preliminary bioassay indicated that compound 5d exhibited similar antifungal activities against Gibber-ella zeae and Cytospora mandshurica at 50 μg/mL,compared with control agent（hymexazol）.In addition,compound 5k possessed higher inhibition rate against G.zeae than hymexazol.