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HE4——卵巢癌和子宫内膜癌的标志物 被引量：5

HE4——Biomarker of Ovarian and Endometrial Cancer
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摘要 人附睾蛋白4(HE4)在卵巢癌和子宫内膜癌高度表达,在患者血清中检测到HE4水平显著升高。而在非妇科肿瘤患者血清中未见HE4升高。HE4较癌抗原125灵敏度高、特异性好,可用于患者确诊、术后复发监视和治疗反应评价等,已经成为盆腔肿瘤新的标志物。现就HE4的结构、表达、作为卵巢癌和子宫内膜癌标志物的价值以及在我国的应用现状等作一综述。 Human epididymis protein 4（HE4）is highly expressed in ovarian and endometrial cancer,and increased serum levels of HE4 are detected in these patients,while there are no increased serum levels of HE4 in non-gynecologic cancer patients.HE4 is more sensitive and specific than cancer antigen 125.HE4 would be useful to aid in cancer diagnosis,detection of recurrence and as evaluation of treatment response.It has become a new marker of pelvic tumors.This review focuses on the structure and the expression of HE4,its value as the marker for ovarian and endometrial cancer and the current application in China.
作者 杨彬 彭林
机构地区 天津市第一中心医院天津市临床检验中心
出处 《医学综述》 2011年第20期3087-3089,共3页 Medical Recapitulate
关键词 人附睾蛋白4 卵巢癌 子宫内膜癌 癌抗原125 Human epididymis protein 4 Ovarian cancer Endometrial cancer Cancer antigen 125
分类号 K711.75 [历史地理—世界史]
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参考文献20

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二级参考文献31

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共引文献165

同被引文献44

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引证文献5

二级引证文献10

医学综述
2011年 第20期

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