慢性阻塞性肺疾病及抑郁共病相关研究

Research of Chronic Obstructive Pulmonary Disease Accompanied by Depression Comorbidity

目的探讨慢性阻塞性肺疾病(COPD)、抑郁共病相关干预效果。方法随机将COPD、抑郁共病的患者分为两组,治疗组在常规药物治疗的基础上加用帕罗西汀治疗及心理干预治疗,对照组仅予常规治疗。结果治疗组抑郁症状、肺功能改善较对照组明显,年平均住院次数、住院时间、临床症状缓解时间较对照组缩短,其差异有统计学意义(P<0.05)。结论 COPD患者常伴有抑郁症状,重视和兼顾抗抑郁诊治对缓解患者临床症状、减少住院时间、降低年平均住院率颇有必要。

Objective To explore the related intervention effect of the chronic obstructive pulmonary disease（COPD）with depression.Methods Patients of COPD with depression were randomly divided into two groups,the treatment group was given the routine therapy plus the use of paroxetine treatment and psychological intervention,and the control group was only given routine treatment.Results The depressive symptoms and pulmonary function of the treatment group improved significantly.Average hospitalization frequency,time and the symptom relief time were reduced or shortened,the difference to the control group was statistically significant（P0.05）.Conclusion Accompanied symptoms of depresion are often seen in patients with COPD,attention and consideration to alleviate the antidepressant treatment,is quite necessary to relieve the the clinical symptoms,reduce hospitalization time and annual average hospitalization frequency.