HBsAg阳性母亲的婴儿乙肝疫苗免疫效果观察

Observation on immune effect of hepatitis B vaccine in infants born to HBsAg positive mothers

目的比较HBsAg阳性母亲所生婴儿接种不同剂量乙肝疫苗后的免疫效果。方法将HBsAg阳性母亲所生婴儿118例根据知情、自愿原则分为两组,每组59例。分别接种10μg重组酵母乙肝疫苗和20μg重组CHO(中国仓鼠卵巢细胞)乙肝疫苗,检测婴儿出生和12月龄时HBsAg和抗-HBs水平,比较不同剂量疫苗免疫后阻断乙肝病毒母婴传播效果。结果婴儿出生时,接种10μg和20μg乙肝疫苗组婴儿HBsAg阳性率分别为8.47%和5.08%,差异无统计学意义。12月龄随访时,接种10μg和20μg乙肝疫苗的婴儿HBsAg阳性率分别为3.4%和1.7%,抗-HBs阳性率分别为83.1%和88.1%,差异无统计学意义;10μg乙肝疫苗组婴儿抗-HBs无/弱应答率高于20μg组婴儿,差异具有统计学意义(52.5%vs 33.9%,P<0.05)。结论 20μg乙肝疫苗免疫效果优于10μg乙肝疫苗,对于母亲HBsAg阳性的婴儿,建议接种20μg乙肝疫苗。

Objective To investigate the immune effect of different dosages of hepatitis B（HB） vaccine in infants born to HBsAg positive mothers. Methods A total of 118 infants born to HBsAg positive mothers were divided into two groups,and were immunized with recombinant yeast-derived hepatitis B vaccines（10 μg）or recombinant CHO cell derived hepatitis B vaccines（20 g）,respectively.The HBsAg and anti-HBs were detected.The blocking effects of different doses of vaccine on mother-to-infant transmission of hepatitis B virus were compared. Results When the infants were born,HBsAg positive rate were 8.47% and 5.08% in 10 μg group and 20 μg group,respectively,and there was no significant difference between 2 groups.When the infants were 12 months old,HBsAg and anti-HBs positive rates were not statistically significant between 2 groups,but the non（low）-responsive rate in 10 μg group was significantly higher than that in 20 μg group（P0.05）. Conclusion The immune effect of 20 μg vaccine is better than that of 10 μg vaccine for the infants born to HBsAg positive mothers.