听觉事件相关电位对早期血管性认知损害的临床诊断价值

Clinical Diagnostic Value of Auditory Event Related Potentials on Early Stage Vascular Cognitive Impairmen

对血管性痴呆的认识，临床上已十分重视，但对早期尚未达到痴呆程度的血管性认知损害（VCI）患者，临床上十分容易疏忽。由于其临床表现及神经心理学表现的显著异质性，目前，尚无客观统一的诊断标准。

Objective To study the electrophysiological features in patients with early vascular cognitive impairment （VCI）, provide the basis for the diagnosis of non-dementia of vascular cognitive impairment （VCIND）, and to explore the neuropsychological characteristics and the possible pathophysiology mechanism. Methods 50 patients with vascular cognitive impairment, but below the standard of vascular dementia were divided into subcortical ischemic VCIND group （ n = 25） and cortical ischemic VCIND group （ n = 25）, and the 20 nomlal controls （NC） were enrolled. All of them received the P300 test. Results Subcortical ischemic VCIND and cortical ischemic VCIND groups had extended latency and reduced volatility of P300 compared with the normal control group; subeortical ischemic VCIND group had longer P300 latency than that of in cortical ischemic VCIND group, but there was no significant differences in volatility between two groups. Conclusions VCIND patients had P300 latency and amphtude ＇abnormalities, particularly in subcortical ischemic VCIND patients, and related to its neuropsychological characteristics. P300 may be as an indicator of early diagnosis of VCI.