期刊文献+

急性脑梗死患者血脂、脂蛋白、载脂蛋白与C反应蛋白的相关性研究 被引量:7

下载PDF
导出
摘要 目的研究急性脑梗死患者血脂、脂蛋白、载脂蛋白与C反应蛋白的相关性,探讨急性期脑梗死患者血脂、脂蛋白、载脂蛋白水平与炎症反应的关系。方法将105例急性脑梗死患者抽取清晨空腹静脉血送检血脂、脂蛋白、载脂蛋白与C反应蛋白,分别作甘油三酯、总胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、载脂蛋白AI(apoAI)、载脂蛋白B(apoB)、载脂蛋白B/载脂蛋白AI(apoB/apoAI)与C反应蛋白相关性分析。结果 HDL、LDL、VLDL、甘油三酯、总胆固醇、apoB与C反应蛋白无显著相关性,apoAI与C反应蛋白呈负相关(r=-0.22,P<0.05),apoB/apoAI与C反应蛋白呈显著正相关(r=0.34,P<0.01)。结论 apoAI、apoB/apoAI与炎症反应有关,可以将apoAI和apoB/apoAI与C反应蛋白共同检测,作为防治脑梗死的参考指标。
出处 《心脑血管病防治》 2011年第5期366-368,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
  • 相关文献

参考文献8

  • 1Schlitt A,Blankenberg S,Bickel C,et al.Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease[J].lnt J of Cardiol,2005,102(3):477-485.
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33009
  • 3Pepys MB,Hirschfield GM.C-reactive protein:a critical update[J].J Clin Invest,2003,111 (12):1805-1812.
  • 4Glass CK,Witztun JL.Atherosclerosis,the road ahead[J].Cell,2001,104(4):503-516.
  • 5Ji SR,Wu Y,Potempa LA,et al.Effect of modified C-reactive protein on complement activation.A possible complement regulatory role of modified or monomeric C-reactive protein in atherosclerotic lesions[J].Arterioscler Thromb Vasc Biol,2006,26(4):935-941.
  • 6Ji SR,Wu Y,Potempa LA,et al.Interactions of C-reactive protein with low density lipoproteins:implications for an active role of modified C-reactive protein in atherosclerosis[J].Int J Biochem & Cell Biol,2006,38(4):648-661.
  • 7O'Donnell MJ,Xavier D,Liu L,et al.Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study):a case-control study[J].Lancet,2010,10;376(9735):112-123.
  • 8Lablanche JM,Danchin N,Farnier M,et al.Effects of rosuvastatin and atorvastatin on the apolipoprotein B/apolipoprotein A-1 ratio in patients with an acute coronary syndrome:The CENTAURUS trial design[J].Arch Cardiovasc Dis,2008,101 (6):399-406.

共引文献33008

同被引文献50

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33009
  • 2Wada M, Nagasawa H, Iseki C, et al. Cerebral small vessel disease and chronic kidney disease (CKD): results of a cross-sectional study in community-based Japanese elderly. J Neurol Sci,2008, 272(1/2) :36-42.
  • 3Wersching H, Duning T, Lohmann H, et al. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology, 2010,74 ( 13 ) : 1022-1029.
  • 4Elklnd MS, Luna JM, MoonYP, et al. Infections burden and carotid plaque thichness:the northern Manhattan study[ J ]. Stroke,2010,41 (3) : 117 - 122.
  • 5Chiriboga DE, Ma Y, Li W, et al. Seasonal and sex variation of high-sensitivity C-reactive protein in healthy adults : a lon- gitudinal study [ J ]. Clin Chem,2009,55 (2) :313 - 321.
  • 6Farsak B, Yildirir A, Akyan Y, et al. Detection of Chlamydia pneumoniac and helicobacter pylori DNA in human athero- sclerotic plaques by PCR [ J ]. J Clin Microbiol, 2000,38 (12) :4 408 -4 411.
  • 7Gerig R, Ernst B, Wilms B, et al. Gastric Helicobacter pylori infection is associated with adverse metabolic traits in se- verely obese subjects[ J]. Obesity ( Silver Spring ) ,2013, 21(3) :535 -537.
  • 8Rost NS, Wolf PA, Kase CS, et al. Plasma concentration of C-reartireprotein and risk of ischemic stroke and transient ischemie attack: the Framinsham Study. Stroke, 2001, 32(12):2575-2579.
  • 9Ding S, Zhang M, Zhao Y, et al. The role of carotid plaque vulnerability and inflammation in the pathogenesis of acute ischemic ~troke. Am J Med Sci, 2008, 336(1):27-31.
  • 10Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessmen- tstrategies: Part Ⅱ. Circulation, 2003(108):1772-1778.

引证文献7

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部