两种周疗同步放化疗方案治疗晚期宫颈癌的临床研究

A CLINICAL STUDY FOR TREATMENT OF ADVANCED CERVICAL CANCER WITH TWO KIND OF WEEKLY CONCURRENT CHEMORADIATION

目的探讨两种周疗放化疗方案同步治疗晚期宫颈癌的疗效。方法随机分组:①A组:TC方案,每周予紫杉醇(60～80mg/m2)1次,共6次;第1周和第4周予卡铂(剂量按肾小球滤过率及AUC=5确定,若﹤400mg则按实际计算量给药,若>400mg则按400mg給量),化疗当天结束后1 h内予体外放疗。②B组:DDP方案,每周予顺铂(40mg/m2)1次,共6次,化疗当天结束后1 h内予体外放疗。A、B组均采用根治性放疗(体外放疗+192Ir腔内放疗),每周周一至周五放疗。结果 TC方案的近期疗效比DDP方案好(P<0.05),局部复发及远处转移率低,3年生存率高,毒副作用无明显增加。结论 TC周疗放化疗同步治疗方案可提高晚期宫颈癌的疗效。

Objective To investigate the effects of two kind of weekly concurrent chemoradiation therapy on advanced cervical cancer. Methods Randomly divided into A and B groups： （1） A group： TC program was carried out to use Paclitaxel （60 - 80mg/m2） once a week, 6 times. First week and fourth week administrated Carboplatin （ the dosage was determined by the condition of glomerular filtration rate and AUC - 5, actual calculated dosage was given if 〈 400mg and 400rag was given if 〉400rag）. Radiotherapy was offered in lh after chemotherapy ended. （2） B group： DDP program was carried out to use Cisplatin （40mg/m2） once a week, 6 times. Radiotherapy was offered in lh after chemotherapy ended. Radical radiotherapy （radiotherapy plus 192Ir intracavity） from Monday to Friday was taken in both of the groups. Results The short - term effect of TC program was better that of DDP （ P 〈 0.05）. The TC group showed lower local reoccurrence and distant metastasis, higher 3 years surviving and fewer side effects than DDP group. Conclusion TC program for weekly concurrent chemoradiation therapy is obviously promoting the effect of treatment to advanced cervical cancer.