普伐他汀钠对老年患者颈部动脉粥样斑块及血清一氧化氮、血浆内皮素-1水平的影响

EFFECT OF PRAVASTATIN IN ELDERLY PATIENTS WITH CAROTID ARTERY PLAQUE AND SERUM NITRIC OXIDE AND PLASMA ENDOTHELIN-1 LEVELS

目的探讨普伐他汀钠片对老年颈部动脉粥样斑块及血清一氧化氮、血浆内皮素-1水平的影响。方法选择20例颈动脉粥样斑块老年患者,在干预生活方式的基础上给予普伐他汀钠片,于服药后第3、6月测颈动脉内中膜厚度(IMT)、Crouse斑块积分和血清一氧化氮及血浆内皮素-1水平。结果颈部动脉粥样斑块患者用药前颈动脉IMT、血浆内皮素-1水平显著高于正常对照组(P<0.05),一氧化氮水平显著低于正常对照组(P<0.05);普伐他汀钠治疗前后比较,治疗第3、6月时内皮素-1水平明显降低(P<0.01),一氧化氮水平明显升高(P<0.01);颈动脉IM T、斑块总积分降低(P<0.01)。结论普伐他汀钠片具有改善内皮功能、抗动脉粥样硬化、稳定斑块的作用。*

Objective To investigate the effect of pravastatin on aged carotid artery plaque,serum nitric oxide and endothelin-1 levels.Methods 20 patients with carotid atherosclerosis in elderly patients on the basis of lifestyle intervention were treated with pravastatin,carotid artery intima（IMT）,Crouse plaque score,serum nitric oxide and endothelin-1 levels were measured at the beginning of the study（as baseline）,3 months and 6 months after treatment.Results carotid artery plaque in patients before treatment of carotid artery IMT,plasma endothelin-1 levels were significantly higher than the normal control group（P 0.01）,nitric oxide levels were significantly lower than the control group（P 0.05）;as compared with the beginning and the end of pravastatin treatment,endothelin-1 levels were remarkably reduced（P 0.01）,while serum nitric oxide levels were significantly increased（P 0.01）;carotid artery IMTa nd total score of plaque reduced（P 0.01）.Conclusion Pravastatin has the effect of improving endothelial function,anti-atherosclerosis and plaque stability.