AXL激酶与肿瘤(英文)

AXL KINASES AND CANCER

Axl是受体酪氨酸激酶家族(RTKs)成员之一,它与配体生长阻滞特异基因6(Gas6)结合后可以介导细胞外基质到胞质内的信号转导,在细胞生长、增殖和迁移中是一个关键的调节者。最近研究表明,Axl还在肿瘤形成、侵袭和转移方面也有重要的作用。Axl激酶的异常表达和激活将为一些肿瘤细胞的生长提供有利条件。Axl激酶抑制剂将增强肿瘤细胞对细胞毒化合物的敏感性,成为肿瘤治疗中潜在的靶点。本文拟将Axl激酶在肿瘤细胞中的信号转导途径及作为抗肿瘤药物的作用靶点等方面进行综述。*

Axl is a member of the family of receptor tyrosine kinases（RTKs）,It transduces signals from the extracellular matrix into the cytoplasm by binding the specific ligand growth arrest-specific gene 6（Gas 6）,to some extent,Axl has been described as a major effector of cell survival,proliferation and migration.However,recent studies have revealed that Axl also plays an important role in tumor genesis,invasion and metastasis.Abnormal expression and activation of Axl can provide a survival advantage for certain cancer cells.Inhibition of Axl may enhance the sensitivity of cancer cells to cytotoxic agents and would potentially be a novel therapeutic target.