重组人骨形态发生蛋白-2结合纳米晶胶原基骨材料植骨融合在腰椎不稳症中的临床应用

Application of recombinant human bone morphogenetic protein-2 mix with nano-hydroxyapatite collagen for interbody fusion in lumbar segmental instability

目的观察重组人骨形态发生蛋白-2﹙rhBMP-2﹚结合纳米晶胶原基骨材料﹙nHAC﹚行腰椎间融合治疗腰椎不稳症的疗效。方法 2008年1月－2010年12月23例﹙27个节段﹚腰椎不稳患者,所有患者均行腰椎椎弓根螺钉固定系统,辅助以rhBMP-2结合nHAC椎间植入融合椎体。结果全部病例获随访,手术后平均随访13.5月,按照JOA评价标准,优14例,良6例,可3例。优良率86.9%。结论 rhBMP-2结合nHAC行腰椎间融合治疗腰椎不稳症是一种比较理想的治疗方法。

Objective To investigate the clinic effect of the recombinant human bone morphogenetic protein-2 （ rhBMP-2 mix with nano-hydroxyapatite collagen （ nHAC ） to treat lumbar segmental instability. Method From Jan 2008 to Dec 2010, 23 patients （27 segments ）with umbar segmental instability were treated by internal fixation of Lumbar Spon- dylolisthesis assist with rhBMP-2 and nHAC. Result All cases were followed 13.5 months, judge by JOA, excellent 14cas- es, good 6 cases, the good-excellent were 86.9%. Conclusion rhBMP-2 mix with nHAC to treat lumbar segmental insta- bility is a ideal therapy method.