眼针对脑梗死急性期患者内皮素及降钙素的影响

Effect of Eye Acupuncture on Endothelin and Calcitonin in Patients in the Acute Stage of Cerebral Infarction

目的观察眼针疗法对脑梗死急性期患者内皮素(ET-1)、降钙素(CGRP)的影响,探讨眼针疗法的作用机制。方法将120例脑梗死患者随机分为眼针组、对照组,眼针组在药物治疗基础上,根据中医分型辨证取穴治疗;对照组采用单纯药物治疗。结果眼针组急性期总有效率为88.3%,愈显率为71.7%;对照组总有效率为81.7%,愈显率为53.3%,经比较差异有统计学意义(P<0.05),可见眼针组的疗效明显高于对照组。从血浆ET-1、CGRP含量变化看,治疗后两组血浆ET明显降低,血浆CGRP明显增高(均P<0.05),治疗后组间比较差异有统计学意义(P<0.05)。结论眼针疗法辨证取穴,可以调节脑梗死急性期患者血浆ET、CGRP的含量,增加脑梗死病灶局部脑血流量,改善脑缺血状态,是眼针疗法治疗脑梗死急性期的作用机制之一。

Objective To further Investigate the effect of eye acupuncture on endothelin（ET-1） and calcitonin（CGRP） in patients in the acute stage of cerebral infarction and explore the mechanism of action of eye acupuncture therapy.Methods One hundred and twenty patients with cerebral infarction were randomly allocated to eye acupuncture and control groups.The eye acupuncture group received treatment by point selection based on traditional Chinese medical syndrome differentiation and classification in addition to medication and the control group,medication alone.Results The total efficacy rate and the cure-marked efficacy rate for the acute stage were 88.3% and 71.7%,respectively,in the eye acupuncture group and 81.7% and 53.3%,respectively,in the control group.There were statistically significant differences（P0.05）.The therapeutic effect was significantly better in the eye acupuncture group than in the control group.Changes in ET-1 and CGRP contents showed that plasma ET decreased significantly and plasma CGRP increased significantly in the two groups after treatment（both P0.05）.Conclusions Eye acupuncture treatment by point selection based on syndrome differentiation can regulate ET-1 and CGRP contents,increase blood flow in the cerebral infarct and improve cerebral ischemia in the acute stage of cerebral infarction.This is one of the mechanisms of action of eye acupuncture treatment for the acute stage of cerebral infarction.