老年2型糖尿病患者颈动脉内膜中层厚度与白介素6的相关性

Relationship between carotid artery intima-media thickness and serum interleukin-6 in elderly type 2 diabetic patients

目的讨论2型老年糖尿病患者颈动脉内膜中层厚度与白介素（IL-6）的相关性。方法入选老年2型糖尿病患者，共71例，用超声检测颈动脉内膜中层厚度（IMT），并检测血清IL6水平。按照颈动脉IMT进行分组。IMT〈1．0mm者分入IMT正常组，IMT≥1．0mm者分入IMT增厚组。对两组血清IL-6水平进行t检验，对IL-6与IMT进行相关性分析及Logistic回归分析。结果IMT增厚组IL-6水平（41．23±9．66ng／L）高于IMT正常组（31．53±9．23ng／L），P〈0．01；IL-6与糖化血红蛋白及IMT均成正相关，R=0．351，P〈0．01；IL水平升高者颈动脉IMT增厚的风险增加5．57倍（OR=3．81，95％CI1．07～13．66，P〈0．05）。结论血清IL-6水平与颈动脉内膜中层厚度水平有关，并可作为老年2型糖尿病患者动脉粥样硬化程度的参考指标。

Objective To study the relationship between carotid artery intima-media thickness and serum interleukin-6 in elderly type 2 diabetic patients. Methods 71 elderly patiems with type 2 diabetes were retrospectively studied. The levels of carotid intima-media thickness （IMT） were detected by ultrasound. The Serum IL-6 levels were assessed. According to the carotid IMT level, all cases were divided into two groups： normal IMT group （IMT 〈 1.0 mm） and thick IMT group （IMT ≥ 1.0 mm）. Results In the thick IMT group, the serum IL-6 levels were significantly higher than the normal IMT group （P 〈 0.01）; The IL-6 level was positively correlated with glycated hemoglobin and IMT （P〈 0.01）. Conclusions Serum IL-6 is related with carotid artery intima-media thickness, which may be a marker for atherosclerosis in elderly type 2 diabetic patiems.