血清金属元素含量与老年阿尔茨海默病的关系

Correlation between serum trace elements and Alzheimer＇s disease

目的探讨血清金属元素含量与老年阿尔茨海默病的关系。方法随机选择老年科住院的33例阿尔茨海默病（Alzheimer disease，AD）患者以及33例同期住院的认知功能正常的内科疾病患者，对两组人口学统计资料、认知功能及血清26种金属元素含量进行测定并进行比较。结果两组血清金属元素含量测定Zn、Cr、Co、Ni浓度AD组较对照组降低（正态分布元素值Zn0．75±0．20和0．92±0．40；非正态分布元素值Cr28．24和38．76；Co28．17和38．83；Ni27．79和39．21，P〈0．05）结论部分金属元素如Zn、Cr、Co、Ni等可能与AD的病理相关。

objective To explore the correlation between serum trace elements and Alzheimer＇s disease. Methods 33 patients with Alzheimer＇s disease （AD） and 33 controls who have normal cognition were included in this study. The cognition and the concentrations of serum 26 trace elements in the two groups were measured. Sex, age, educational years, history of the diseases, the history of smoking and drinking were registered. Results Some of the concentrations of serum 26 trace elements in the AD group such as Zn, Cr, Co and Ni were statistically lower than those of the controls （the concentrations of the elements which were normal distributed： Zn 0.75 ±0.20 and 0.92 ±0.40; The concentrations of the elements were not normal distributed in Cr 28.24 vs 38.76; Co 28.17 vs 38.83; Ni 27.79 vs 39.21,P〈0.05）. Conclusion Trace elements such as Zn, Cr, Co and Ni might be associated with the pathology of AD.