摘要
目的分析2型糖尿病(T2DM)患者口服75克葡萄糖行胰岛素释放试验中胰岛素释放曲线高峰值后移的发生原因及临床意义,探讨针对此病理改变特点进行糖尿病个体化干预及治疗的可能性。方法 899例入选的T2DM患者全部进行口服75克葡萄糖耐量试验(OGTT)和胰岛素释放试验,对观察对象的血糖及胰岛素释放曲线进行分析。结果 T2DM组有92%的患者胰岛素释放曲线高峰值后移;与胰岛素释放峰值后移相关的因素有6个,其中胰岛素抵抗对胰岛素释放峰值后移危险最大,OR值为2.446。结论胰岛素释放曲线高峰值后移是T2DM胰岛素抵抗对胰岛β细胞分泌功能损伤的特点之一,可作为初诊T2DM鉴别诊断的依据,胰岛素释放峰值后移是由于胰岛素抵抗及胰高糖素分泌亢进,胰岛β细胞分泌功能降低导致的,在临床上早期T2DM出现次餐前低血糖与该病理改变有关。
Objective To investigate the causes and clinical significance of delayed peak of insulin release in type 2 diabetes（T2DM） patients,evaluate the possibility of the individual intervention and treatment for diabetes according to the pathological features after glucose 75 g po and insulin releasing test（IRT）.Methods A total of 899 cases of T2DM were selected and underwent 75 g oral glucose tolerance test（OGTT） and IRT.Blood glucose and insulin releasing curve were observed and analyzed.Results Delayed peak of insulin release was found in 92% T2DM patients.There were 6 factors correlated with the delay of insulin releasing peak.Insulin resistance was the main risk factor of delayed peak of insulin release（OR： 2.446）.Conclusion Delayed peak of insulin release is one of the characteristics of β-cell dysfunction caused by insulin resistance.Also,it can be used as an evidence of preliminary diagnosis of T2DM.Delayed peak of insulin release is caused by insulin resistance,hypersecretion of glucagon and β-cell dysfunction,which is clinically correlated with the hypoglycemia before meal in early T2DM patients.
出处
《实用医院临床杂志》
2011年第6期83-85,共3页
Practical Journal of Clinical Medicine
基金
四川省科技厅重点支撑课题(编号:416001004069)
