汶川地震对灾区人群血浆同型半胱氨酸水平的影响

Influence of Wenchuan earthquake on serum homocysteine level of victims

目的探讨地震对灾区人群血浆同型半胱氨酸(homocysteine,HCY)水平的影响。方法随机抽取150名汶川地震灾民(研究组)、150名健康体检者(对照组)进行心理问卷调查,测定血浆HCY水平。结果研究组症状自评量表得分显著高于对照组,血浆HCY水平显著高于对照组[(24.4±10.9)μmol/L vs(17.2±3.8)μmol/L,P<0.01];血浆HCY水平与焦虑自评量表(Self-Rating Anxiety Scale,SAS)和抑郁自评量表(Self-Rating Depression Scale,SDS)得分呈正相关(HCY与SAS:r=0.968;HCY与SDS:r=0.979,均P<0.01)。结论地震可引起灾民生理应激状态,导致机体血浆HCY水平升高。

Objective The aim of the study was to investigate the influence of earthquake on serum homocysteine（HCY） level in victims.Methods A total of 150 victims were assigned to study group and 150 healthy individuals were assigned to control group.The mental status of the two groups was investigated with Self-Rating Anxiety Scale（SAS） and Self-Rating Depression Scale（SDS）.The level of serum HCY was detected.Results The questionnaire score of study group was higher than that of control group.The level of serum HCY of study group was significantly higher than that of control group[（24.4±10.9） μmol/L vs.（17.2±3.8） μmol/L,P 0.01].There was a positive correlation between Hcy and SAS（r = 0.968,P 0.01） as well as Hcy and SDS（r = 0.979,P 0.01）.Conclusions Earthquake can cause physical stress for victims,which leads to the increase of serum HCY level.