进口替米沙坦治疗老年高血压伴葡萄糖耐量异常的临床研究

Clinical study of Telmisartan in treatment of elderly hypertension with impaired glucose tolerance

目的观察进口替米沙坦对老年高血压伴葡萄糖糖耐量异常患者血糖及血压的影响。方法收集我院2008年9月至2010年9月60～80岁高血压伴糖耐量异常患者160例,随机数字表法分为两组。试验组采用替米沙进口坦80 mg口服,对照组采用进口雷米普利5 mg口服,均1次/日,疗程6个月。观察两组降压效果、对糖代谢的影响、肝肾功能及血脂谱的变化、咳嗽及血管神经水肿等不良反应的发生率。结果试验组患者血糖、血脂、胰岛素抵抗较对照组有明显改善,差异有统计学意义(P<0.05)。结论进口替米沙坦除具有降压作用外,还能改善糖脂代谢,预防糖尿病的发生,患者咳嗽发生率低,耐受性好。

Objective To observe the effect of Telmisartan on blood glucose and blood pressure of elderly patients with hypertension and impaired glucose tolerance.Methods A total of 160 60 to 80-year-old patients with hypertension and impaired glucose tolerance from September 2008 to September 2010 were randomly divided into two groups.The experimental group was treated with oral administration of Telmisartan 80 mg,q.d.The control group was treated with oral administration of Ramipril 5 mg q.d.The courses of treatment were both 6 months.We observed the incidence of adverse reactions such as antihypertensive effect,effect on glucose metabolism,changes in liver and kidney function,lipid profile changes,cough and angioneurotic edema etc..Results In Telmisartan group,the patients＇ glucose,blood lipids and insulin resistance significantly improved compared with that in control group.（P0.05）.Conclusion Besides antihypertensive effect,Telmisartan can improve glucose and lipid metabolism and prevent diabetes,with low incidence of cough and good tolerance by patients.