治疗癌症的新途径:靶向肿瘤微环境

A novel cancer therapeutic strategy:targeting tumor microenvironment

传统的癌症治疗方法是以直接杀死肿瘤细胞为基础,近年来靶向肿瘤微环境成为治疗肿瘤的新途径。肿瘤微环境主要通过诱导新生血管形成、抑制免疫监视和免疫反应、孕育肿瘤干细胞等促进肿瘤发生及转移。理论上靶向肿瘤微环境的肿瘤治疗应有高效、低毒、广谱的特点。限于对肿瘤微环境的了解,目前以肿瘤微环境为靶成功治疗肿瘤的例子并不多。本文就肿瘤微环境对肿瘤的调控、靶向肿瘤微环境治疗肿瘤的现状、存在的问题及发展趋势进行综述。

Conventional cancer therapies are based on killing tumor cell directly.Recently,targeting tumor microenviron-ment becomes a novel approach for cancer treatment.The tumor microenvironment may promote tumor formation and metastasis mainly via angiogenesis induction,suppression of immune surveillance and immune response,and breeding tumor stem cells.Targeting therapy at tumor microenvironment theoretically has several characters,such as strong effect,low toxicity and broad anti-tumor spectrum.However,there are few succeedful precedents in tumor treatment targeting tumor microenvironment.In this paper,we summarize the regulation effect of tumor microenvironment on the pathogenesis of tumor,present status,problems and developments trendency of targeting tumor microenvironment.