美沙拉嗪联合川芎嗪治疗溃疡性结肠炎的临床疗效

The clinical effect of mesalazine combined with ligustrazine in treating ulcerative colitis

目的:观察美沙拉嗪联合川芎嗪治疗溃疡性结肠炎的临床疗效。方法:将60例溃疡性结肠炎患者随机分为对照组及观察组,每组30例。在溃疡性结肠炎常规治疗的基础上,对照组给予美沙拉嗪1.0g,3次/d;观察组同时给予盐酸川芎嗪葡萄糖注射液100ml,1次/d静脉滴注及美沙拉嗪1.0g,3次/d;两组疗程均为8周。8周后评价疗效。结果:观察组总有效率为90%,显效率为70%,均高于对照组的80%及50%,差异有统计学意义(P<0.05)。结论:美沙拉嗪和川芎嗪联合治疗溃疡性结肠炎具有更好的临床疗效,能较好地改善患者的临床症状及体征。

0bjective： To evaluate the effect of mesalazine combined with ligustrazine in treating ulcerative colitis patients. Methods： Sixty patients with ulcerative colitis were randomly divided into observation group and control group, thirty patients in each group. On the foundation treatment of ulcerative colitis, the control group received mesalazine 1.0 g, three times a day. And at the same time the observation group received Ligustrazine glucose 100 ml one time each day by injection. All the patients received a course of 8 weeks. Then the effect of the treatment was evaluated. Results： The total effective rate and significant efficiency rate of observation group were 90% and 70%, compared with control group＇s 80% and 50%, the diference was statistically significant （P0.05）. Conclusion： The combination therapy in treatment of ulcerative colitis is better. It can improve the patient＇s clinical symptoms and signs better.