血府逐瘀汤对急性肺挫伤后炎性因子影响的临床研究

Clinical study of Xuefu Zuyu Decocotion on inflammatory factors in Patients with Acute Pulmonary Contusion

目的观察血府逐瘀汤对急性肺挫伤患者血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)的影响。方法选择60例肺挫伤患者,随机分为对照组和治疗组各30例。两组均给予吸氧、雾化吸入、止血、抗感染、营养、药物外敷等常规治疗,治疗组在此基础上加用血府逐瘀汤(由桃仁、红花、当归、生地、赤芍、川芎、柴胡、枳壳、桔梗、牛膝、甘草等11味药组成)治疗,对照组则加用曲马多缓释片口服治疗,两组疗程均为1周。观察肺挫伤后继发性肺损伤情况和患者康复时间,记录并比较各组动脉血气分析结果;血清TNF-α、IL-6水平变化情况。结果治疗组患者的血清TNF-α、IL-6水平较对照组有明显的降低(P<0.05),康复时间显著缩短(P<0.05)。在继发性肺损伤方面,治疗组无出现肺部感染和急性呼吸窘迫综合征(ARDS);对照组2例发生肺部感染,1例出现ARDS。结论血府逐瘀汤能显著降低患者TNF-α、IL-6水平,阻断肺损伤的演变进程,缩短康复时间,表明血府逐瘀汤对肺挫伤有明显的治疗作用。

Objective To investigate the effect of Xuefu Zuyu Decoction on serum inflammatory cytokines of tumor necrosis factor（TNF）-α and interleukin-6（IL-6） in acute pulmonary contusion patients. Methods Sixty acute pulmonary contusion patients were equally randomized into the control group（receiving routine medical treatment and use of Tramadol） and the treatment group（receiving routine medical treatment and use of Xuefu Zuyu Decocotion）.The treatment lasted for 1 week.Secondary pulmonary contusion,recovery time and the serum levels of TNF-α and IL-6 were observed.Results Serum levels of TNF-α and IL-6 in the treatment group were decreased（P0.01）,and the recovery time was shortened as compared with those in the control group（P0.01）.In the treatment group,there was no patient with acute respiratory disease syndrome（ARDS） while one in the control group;there were 2 patients with pulmonary infection in the control group.Conclusion Xuefu Zuyu Decoction is effective for acute pulmonary contusion by depressing the serum levels of TNF and IL-6,blocking the progress of contusion and shortening the recovery time.