^(99)Tc-MDP治疗股骨头缺血性坏死临床应用

Clinical Application of ^(99)Tc-MDP in the Treatment of Osteonecrosis of Femoral Head

探讨99Tc-MDP(商品名:云克)治疗股骨头缺血性坏死的机制及临床疗效。用99Tc-MDP治疗经影像学和临床诊断的股骨头缺血性坏死83例,并对治疗前后疼痛、生活能力、关节活动度及行走距离进行评分比较,观察分析临床疗效。统计学分析采用SPSS16.0软件,P<0.05认为有统计学差异。平均随访12个月,各期患者疼痛、生活能力治疗前后评分差异均有显著性意义(P<0.05),Ⅱ、Ⅲ期患者关节活动度及行走距离治疗前后评分差异亦有显著性意义(P<0.05)。随访18月以上者,81.8%X射线摄片显示股骨头有修复改变。99Tc-MDP治疗股骨头缺血坏死可改善股骨头血液供应,临床疗效满意。

To explore the mechanism and therapeutic effect of 99Tc-MDP on the treatment of osteonecrosis of femoral head.The eighty-three patients with osteonecrosis of femoral head confirmed by X-ray examination were treated by 99Tc-MDP.The scores of pain,viability activity of joints and walking distance and the clinical effects were observed and analyzed.All patients were followed up in an average period of 12 months.The results showed that the scores of pain and viability of each period after therapy were significantly greater than that before therapy（P〈0.05）.The scores of activity of joints and walking distance of the second and the third period after therapy were significantly greater than that before therapy（P〈0.05）.The X-ray film results indicated that 81.8% patients followed up more than 18 months showed reparation change of the femoral head.The treatment of osteonecrosis of femoral head by 99Tc-DP could improve the blood supply of the femoral head,and achieve satisfactory effects.