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表面改性对羟基磷灰石蛋白吸附的影响 被引量：1

Effect of Surface Modification on Protein Adsorption Characteristics of Hydroxyapatite
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摘要 采用原子转移自由基聚合(ATRP)在羟基磷灰石(HAP)纳米粒子表面接枝了聚甲基丙烯酸甲酯(PMMA)。随着接枝的PMMA含量增加,改性粒子在水溶液中的分散性增强。以牛血清白蛋白(BSA)和溶菌酶(LSZ)为吸附目标,研究了HAP和改性后的粒子(g-HAP)的蛋白质吸附性能。结果发现,g-HAP比HAP对蛋白质的单位吸附量大,表面接枝PMMA可以增加HAP对蛋白质的吸附。 Hydroxyapatite（HAP） nanoparticles were surface grafted with poly（methyl methacrylate）（PMMA） through atom transfer radical polymerization（ATRP）.As the amount of grafted PMMA increased,the dispersibility of surface-grafted HAP（g-HAP） in aqueous solution was improved.Bovine serum albumin（BSA） and lysozyme（LSZ） were selected as models to study their adsorption behaviors on HAP and g-HAP.Our results showed that the adsorption capacity on g-HAP was higher than that on HAP,indicating that the adsorptive property of HAP was improved due to surface modification of HAP with PMMA.
作者 王岩 肖艳 郎美东
机构地区 华东理工大学材料科学与工程学院
出处 《华东理工大学学报（自然科学版）》 CAS CSCD 北大核心 2011年第5期565-570,共6页 Journal of East China University of Science and Technology
基金 中央高校基本科研业务费专项资金(WD0913008,WD1014017) 上海市曙光学者计划 上海市自然科学基金(11ZR1409200) 上海市重点学科和重点实验室项目(B502,D8DZ2230500)
关键词 羟基磷灰石 表面改性 分散性 蛋白质吸附 hydroxyapatite surface modification dispersibility protein adsorption
分类号 O631 [理学—高分子化学]
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参考文献16

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共引文献82

同被引文献10

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华东理工大学学报（自然科学版）
2011年 第5期

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