某市老年人血清维生素B_(12)、叶酸及同型半胱氨酸水平与季节变化的关系

The effect of season on the levels of serum vitamin B_(12),folate and homocysteine in elderly people of certain city

目的探讨哈尔滨市老年人血清中维生素B12、叶酸以及同型半胱氨酸水平是否随季节改变发生变化。方法选取151例研究对象,在冬春季和夏秋季分别采血1次,采用荧光偏振法测定同型半胱氨酸,微粒子技术测定叶酸和维生素B12,同时进行比较。结果冬春季血清中维生素B12、叶酸水平明显低于夏秋季,差异有统计学意义(P<0.05),而同型半胱氨酸水平没有呈现季节性变化。结论哈尔滨市老年人在冬春季应该适量服用维生素B12、叶酸,以预防疾病的发生。

Objective To investigate whether the levels of serum vitamin B and homocysteine in elderly people of Haerbin city were correlated.Methods 151 subjects were enrolled and were drawn blood once in winter/spring and once in summer with seasons fall.The Homocysteine levels were measured by fluorescence polarization,Vitamin B12 and folate were measured by macroparticle technology.The levels of vitamin B12,folate and homocysteine in winter/spring were compared to those in summer with seasons fall.Results The levels of vitamin B12 and folate in winter/spring were significantly lower than those in summer/fall（P0.05）.However,the level of homocysteine did not change with the change of seasons.Conclusion Elderly people of Haerbin city should take in moderate dosage of vitamin B12 and folate in order to prevent occurrence and development of diseases.