体检人群乙型肝炎标志物3项抗体阳性者性别、年龄分布与肝功能及血脂水平关系研究

The relationship between sex and age distribution with liver function and serum lipid level in individual positive with three anti-HBV antibodies

目的了解乙型肝炎病毒标志物(HBV-M)3项抗体(HBsAb、HBeAb、HBcAb)均阳性者在体检人群中的分布。方法对21 084例浙江省各阶层人群及男、女健康对照组,分别检测HBV-M、肝功能、血脂、体质量指数(BMI),对HBV-M 3项抗体均阳性者性别、年龄分布及肝功能指标、血脂水平、BMI及饮酒习惯的关系进行研究。结果 21 084例体检人群筛选出HBV-M 3项抗体均阳性者305例,男性155例(1.14%)、女性150例(2.01%),女性组比例高于男性组,差异有统计学意义(P<0.01);男性组平均年龄(45.52±12.56)岁,女性组(40.47±11.17)岁,女性组明显低于男性组,差异有统计学意义(P<0.01);女性组在20～39岁、40～59岁、≥60岁年龄段阳性率分别为2.46%、1.81%、0.97%,差异有统计学意义(P<0.05);男性组与男性健康对照组相比,ALT、AST、γ-GT、BMI差异均有统计学意义(P<0.01),而女性组与女性健康对照组之间则差异无统计学意义(P>0.05)。结论体检人群中HBV-M 3项抗体均阳性者比例女性组高于男性组,3项抗体均阳性者女性组平均年龄小于男性组;男性组肝功能指标高于对照组,与3项抗体阳性无相关性,与BMI及饮酒习惯相关。

Objective To understand the positive rate and clinical significance of the individuals positive with three anti-HBV antibodies（anti-HBs,anti-HBe,Anti-HBc） in health examination.Methods A total 21 084 subjects from different stratum in Zhejiang Province were measured for HBV markers,liver function,blood lipid,body mass index.Relationship between sex and age distributions with liver function,blood lipid level,body mass index and drink history were analyzed in individuals positive with three anti-HBV antibodies.Results Among total 21 084 subjects,305 cases were positive with the three anti-HBV antibodies,with 155（1.14%） of male and 150（2.01%） of female.The positive ratio in the female group was higher than that in the male group（P0.01）.The average age in the male group was（45.52±12.56）,significantly higher than that in the female group with（40.47±11.17）.The positive ratio was 2.46%,1.81%,0.97% respectively in 20~39,40~59 and at least 60 years old group in female group,and there was statistical significance among the three groups（P0.05）.The levels of ALT,AST,γ-GT and body mass index in the male group were significantly different from those in the male control group（P0.01）.There was no difference between the female groups and the female control group（P0.05）.Conclusion The positive ratio of the three anti-HBV antibodies in female was higher than that in the male.In individuals positive with the three antibodies,female was younger than male.The levels of liver function in the male group were higher than those in the control group,and had no correlation with the positivity of the three antibodies,but with body mass index and drink history.