胃癌侵袭转移的影响因素分析及靶向治疗进展

Prognostic factors of the invasion and metastasis of gastric canc- er and their applications in targeted therapy

肿瘤的侵袭和转移是决定疾病转归的关键因素，胃癌侵袭转移过程中影响因素包括生长因子及其受体、细胞黏附分子、基质降解酶和细胞周期调控等，研究这些影响因素的作用机制，不仅对胃癌侵袭转移的早期诊断具有重要的临床意义，而且对相关靶向治疗药物的研发有重要的社会价值。

Invasion and metastasis are critical determinants on cancer morbidity. Genes and molecules participating in these steps have been demonstrated as potential prognostic factors. Growth factors and their receptors, cell-cycle regulators, cell-adhesion molecules and m, trix-degrading enzymes are potentially used as prognostic factors. However, increased understandings for molecular mechanisms underlying carcinogenesis and its implementation in the treatment of gastric cancers have recently been focused on the development and incorporation of targeted agents with chemotherapy.