喹硫平与利培酮治疗精神分裂症的对照研究

A comparative study between Quetiapine and Risperidone in the treatment of schizophrenia

目的:探讨喹硫平治疗精神分裂症的疗效及安全性。方法:将40例患者随机分为两组,分别给予喹硫平与利培酮治疗,疗程8周。采用阳性和阴性症状量表(the postitve and negative syndrome scale,PANSS)和副反应量表(treatment emergent symptoms scale,TESS)评定疗效及不良反应。结果:喹硫平与利培酮治疗精神分裂症疗效相当,两组PANSS评分差异无显著性(P>0.05);两组TESS发生率比较,喹硫平组不良反应少(P<0.05)。结论:喹硫平是治疗精神分裂症安全、有效的药物。

Objective：To explore the efficacy and safety of Quetiapine in the treatment of schizophrenia.Methods：40 schizophrenics were randomly divided into two groups,with Quetiapine or Risperidone for eight weeks.The efficacy and side effects were assessed with PANSS and TESS.Results：No remarkable differences were found in PANSS scores between the two groups,but the side effects of Quetiapine were fewer than that of Risperidone.Conclusion： Quetiapine is an effective and safe drug in the treatment of schizophrenia.