齐拉西酮对长期住院慢性精神分裂症患者认知功能的疗效分析

The effect of Ziprasidone on the cognitive function in the long-term hospitalization chronic schizophrenia patients

目的:评价齐拉西酮对长期住院慢性精神分裂症患者认知功能的疗效。方法:将80例慢性精神分裂患者随机分两组,分别用齐拉西酮治疗(单用组)及维持原有治疗(维持组),应用韦氏智力量表(WAIS-RC)、韦氏记忆量表(WMS)、威斯康星量表分类试验、逻辑记忆测验评定患者认知能力。结果:治疗结束时单用组较维持组的评分均显著降低(χ2=6.65,P<0.01),且不良反应少(χ2=4.11,P<0.05)。结论:齐拉西酮对长期住院慢性精神分裂症患者认知功能有良好的临床应用价值。

Objective：To explore the effect of Ziprasidone on the cognitive function in the long-term hospitalization chronic schizophrenia patients.Methods：Eighty chronic schizophrenia patients were randomly divided into Ziprasidone group（single drug treatment） and maintained group（all patients received antipsychotic drugs and were maintained on these drugs without change throughout the study period）.The Wechsler Intelligence Scale（WAIS-RC）,Wechsler Memory Scale（WMS）,Wisconsin Card Sorting Test（WCST） and the Logical Memory Test（LMT） were examined before and after the treatment.Results：The cognitive function points in Ziprasidone group was significantly lower than the maintained group after treatment（χ^2=6.65,P〈0.01）,and less adverse reactions（χ^2=4.11,P〈0.05）.Conclusion：Ziprasidone can improve the cognitive function in the long-term hospitalization chronic schizophrenia patients.