骨硬化蛋白与骨代谢

Sclerostin and bone metabolism

骨硬化蛋白(sclerostin),曾称硬骨素,由SOST基因编码,是一种分泌型糖蛋白。体内研究证明,骨硬化蛋白特异性地表达于骨细胞(osteocyte)中,通过作用于成骨细胞而在骨代谢中起重要作用。骨硬化蛋白基因(SOST)的表达受应力作用、激素、氧浓度等因素的影响。拮抗骨硬化蛋白可以缓解骨质疏松的症状,这为临床治疗骨质疏松等疾病提供了新思路与新方法。本文在介绍骨硬化蛋白的表达定位与分子结构的基础上,就其参与骨代谢的最新研究进展做一综述。

Sclerostin encoded by SOST gene is a secreted glycoprotein.Sclerostin is expressed exclusively by osteocytes in vivo and plays an important role in bone metabolism by affecting osteoblast’s function.The expression of sclerostin（SOST） is influenced by mechanical stimulus,hormone,oxygen and other factors.Antagonising sclerostin can reduce the degree of osteoporosis,which would provide novel insights and methods for clinical treatment of osteoporosis.With the introduction of the location and molecular structure of sclerostin,this paper has reviewed the recent advances on sclerostin’s function in bone metabolism.