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α-黑素细胞刺激素作用的信号转导机制 被引量：4

Mechanisms of α-melanocyte-stimulating hormone in different cells
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摘要 α-黑素细胞刺激素(α-MSH)是来源于阿黑皮素原的一种神经内分泌免疫调节肽。本文综述了近年来对α-MSH作用的信号转导机制的研究进展,包括α-MSH在调节黑素生成,保护黑素细胞,抗炎,抑制摄食,介导脱敏,调节B细胞生长及调控皮肤光老化过程中的相关信号转导机制。 α-Melanocyte-stimulating hormone（α-MSH） is a neuroendocrine-immune regulation peptide derived from the proopiomelanocortin.α-MSH is involved in modulating melanogenesis,melanocyte protection,anti-inflammation,food intake,receptor desensitization,B cell growth and skin aging.In this paper,recent advances on the signal transduction mechanisms underlying the biological functions of α-MSH were reviewed.
作者 闵彦 田野苹
机构地区 第二军医大学免疫学研究所 济南军区总医院实验诊断科
出处 《生命的化学》 CAS CSCD 北大核心 2011年第5期671-674,共4页 Chemistry of Life
关键词 Α-黑素细胞刺激素 信号转导 黑素细胞 摄食 脱敏 α-MSH signal transduction melanocyte food intake desensitization
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献20

  • 1Brzoska T et al. α-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev, 2008; 29: 581-602.
  • 2Marina T et al. Melanocyte function and its control by melanocortin peptides. J Histochem Cytochem, 2002, 50:125-133.
  • 3Dong Y et al. Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to α-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor. Biochem Biophys Res Commun, 2010, 396:849-853.
  • 4Choi MY et al. Whitening activity of luteolin related to the inhibition of cAMP pathway in α-MSH-stimulated B 16 melanoma cells. Arch Pharm Res, 2008, 31 : 1166-1171.
  • 5Jang JY et al. Partially purified curcuma longa inhibits α-melanocyte- stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signaling in B16F10 cells. Exp Dermatol, 2009, 18:689-694.
  • 6Isoldi MC et al. Light modulates the melanophore response to α-MSH in Xenopus laevis: an analysis of the signal transduction crosstalk mechanisms involved. Gen Comp Endocrinol, 2010, 165:104-110.
  • 7Li D et al. Diminishment of α-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages. J Leukoc Biol, 2008, 84:191-198.
  • 8Luger TA et al. α-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis, 2007, 3(Suppl): iii52-iii55.
  • 9Mastrofrancesco A et al. KdPT, a tripeptide derivative of α-melanocyte-stimulating hormone, suppresses IL-1 β-mediated cytokine expression and signaling in human sebocytes. J Immunol, 2010, 185: 1903-1911.
  • 10Getting SJ et al. Melanocortin peptide therapy for the treatment of arthritic pathologies. Scientific World Journal, 2009, 9:1394-1414.

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生命的化学
2011年 第5期

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