欧维婷软膏配伍米索片应用于绝经后妇女取环

Compatible application of estriol ointment and misoprostol tablets in IUD removal in postmenopausal women

目的 探讨欧维婷软膏配伍米索前列醇片在绝经后妇女取环中的效果.方法 对200例绝经后要求取环妇女随机分为欧维婷配伍米索组（实验组）和米索组（对照组）各100例.实验组术前7天予以欧维婷软膏0.5g/d,睡前阴道上药,第8天术前2小时经阴道上米索前列醇片600μg;对照组仅用米索前列醇片600μg,取环术前2小时经阴道上药.观察两组术中宫颈软化情况、疼痛程度、手术时间、取环成功率及药物副反应.结果 两组疼痛程度比较无显著性差异（P〉0.05）;两组在宫颈软化、手术时间及取环成功率方面比较均有显著性差异（χ2=14.788、t=-7.850、χ2=6.213,均P〈0.05）.结论 欧维婷软膏配伍米索前列醇片有协同增效作用,应用于绝经后妇女取环安全、有效,成功率高,是一种值得临床推广使用的方法.

Objective To explore the compatible effect of estriol ointment and misoprostol tablets in intrauterine contraceptive device （IUD） removal in postmenopausal women. Methods 200 postmenopausal women requiring removal of IUD were randomly divided into estriol ointment with misoprostol group（ experimental group） and misoprostol group（ control group） with 100 cases in each. Estriol ointment （0.5g/d） was given in vagina at bedtime for seven days in experimental group, and 600μg misoprostol was given by vaginal 2 hours before removing at 8th day. In control group only 600μg misoprostol was given by vaginal 2 hours before IUD removal. The extent of cervical softening, pain degree, operative time, success rate of removal and side-effect of misoprostol were observed. Results There was no significant difference in pain degree （ P 〉 0.05 ） , but the differences in extent of cervical dilatation, operative time and success rate of removal between two groups were significant （χ2 = 14. 788, t = -7. 850, χ2 = 6. 213, all P 〈0.05 ）. Conclusion The results suggest the synergistic interaction of estriol ointment and misoprostol tablet. It is safe and effective in the removal of IUD in postmenopausal women with high success rate, and it is worth popularizing in clinics.