妇女绝经后反复下尿路感染126例临床观察

Clinical observation of levofloxacin combined with estrogen ointment for repeated urinary tract infection in postmenopausal women

目的 探讨女性绝经后反复下尿路感染的治疗方法.方法 分析126例绝经后反复下尿路感染患者的治疗情况.治疗组63例,采用小剂量抗生素与外用雌激素软膏结合治疗;对照组63例,单用小剂量抗生素治疗.比较两组的治疗效果.结果 小剂量抗生素结合雌激素软膏外用治疗绝经后妇女尿路感染总有效率85.71%,较单用小剂量抗生素的对照组（73.02%）有显著性差异（χ2=6.490,P〈0.05）.治疗组尿道刺激症状消失时间、下腹疼痛消失时间、肉眼血尿消失时间、尿常规恢复正常时间均明显少于对照组,经比较具有显著性差异（t值分别为-4.458、-5.116、-5.300、-3.454,均P〈0.01）.结论 对绝经后反复下尿路感染患者采取服用小剂量抗生素及尿道外口外用雌激素软膏等综合措施治疗效果较好.

Objective To investigate the treatment for repeated urinary tract infection in postmenopausal women. Methods The treatments of 126 cases were analyzed. The treatment group （63 cases） was treated with small dose of levofloxacin plus estrogen ointment, while the control group （63 cases） was treated only with small dose of antibiotics. The therapeutic effect of two groups was compared. Results The clinical efficiency of treatment group was 85.71%, which was significantly different from that （73.02%） of control group （χ2 = 6. 490, P 〈 0.05 ） . The disappearance time of urethral stimulant symptom, of lower abdominal pain, of gross hematuria and the time of recovery of urine routine of the treatment group were obviously shorter than those of the control group, and the differences were significant （ t value was - 4.458, - 5. 116, - 5. 300 and - 3. 454 respectively, all P 〈 0.01 ）. Conclusion The therapeuticceffect of small dose of levofloxacin combined with estrogen ointments is comparatively good.