魔芋粉片剂的制备研究

Preparation of konjac flour tablets

目的:研制魔芋粉片剂。方法:在用单因素实验选择崩解剂和填充剂的基础上,采用以硬度和崩解时限为指标的正交实验设计确立最佳配方。结果:选用8%羧甲基淀粉钠(CMS-Na)、0.3%硬脂酸镁、3%聚维酮K30、30%可压性淀粉(PCS),所得片剂崩解性能优良,各项指标均符合《中国药典》2005版相关规定。

Objective：To prepare konjac flour tablets.Method：Design single factor tests to compare different disintegrants and filler.Then,disintegration time and hardness as index,the formulation of konjac flour tablets was optimized by orthogonal design test.Results：The optimized konjac flour tablets,which were prepared by selecting 8% CMS-Na,0.3% magnesium stearate,3% K30,30% PCS.The disintegration of above formulation was excellent,and all its indexes were conformed to the requirement of China Pharmacopoeia.