吸烟患者颈动脉内膜中层厚度与动脉弹性的相关性研究

Assessments of correlation between intima-media thickness and elasticity of carotid in patients with smoke

目的:应用血管内中膜分析技术(QIMT)和动脉僵硬度分析技术(QAS)评价吸烟患者颈动脉内膜一中层厚度与弹性的相关性。方法:随机选取吸烟患者(年龄<35岁)80例作为病例组,40例同期健康志愿者为对照组。应用QIMT和QAS技术对颈动脉进行检查,获得颈动脉的内膜一中层厚度(IMT)、顺应性系数(CC)、扩张性系数(DC)、僵硬度系数(β)。病例组再根据IMT分组;IMT<0.9mm为病例1组,1组患者再根据吸烟量分为1a组(烟龄小于5年,且<20支/d)及1b组(烟龄>5年,且>20支/d),IMT≥0.9mm为病例2组。结果:对照组、病例1a组、病例1b组,病例2组的DC、CC差异有统计学意义(P<0.05),对照组>病例1a组>病例1b组>病例2组。病例组的β与吸烟、颈动脉IMT呈明显正相关。β与吸烟量r=0.789,P=0.00;β与颈动脉IMTr=0.715,P=0.000。结论:QIMT可较准确地测量颈动脉IMT,QIMT与QAS技术联合应用使颈动脉的解剖结构成像与功能成像有机地结合,可成为深入研究颈动脉早期结构和功能改变的有效手段。

Objective To investigate the correlation between intima-media thickness （IMT） and common carotid artery elasticity in patients with smoke by quantitative intima-media thickness （QIMT） and quantitative arterial stiffness （QAS） techniques. Methods Eighty patients with smoke were involved in the study as case group. Forty healthy volunteers were supplied as normal control group in the same period. IMT, compliance coefficient （CC）, distensibility coefficient （DC） and stiffness index（β） of carotid were acquired through QIMT and QAS. Case group was divided into case group 1 （IMT 〈 0.9 mm） and case group 2 （IMT ≥ 0.9 ram）. Case group 1 was further divided into two sub-groups： group la and group lb,and analysis was performed. Results β and IMT had significant differences in case group la, case group lb,case group 2 and controI group （P 〈 0.05）, control group 〈 case group la 〈 case group lb 〈case group 2. DC and CC had significant differences in case group 1a,case group 1b, case group 2 and control group（P 〈 0.05 ）, control group〉case group la〉 case group lb〉case group 2. There was significant positive correlation between β, quantity of smoke and IMT of carotid respective （r = 0.789, r = 0.715）. Conclusions IMT of carotid could be measured accurately by QIMT. Structure imaging and functional imaging of carotid might be combined organically through QIMT and QAS. Depth study about early change of carotid in structure and function could be performed with these two techniques.