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Caveolin-1和survivin在肾癌中的表达及临床意义 被引量：1

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摘要 目的:探讨小窝蛋白-1(caveolin-1)和存活素(survivin)在肾细胞癌(RCC)中的表达及其临床意义。方法:采用免疫组化PV-9000法检测95例RCC标本和14例正常肾组织中caveolin-1和survivin的表达情况,并分析其相关性。结果:在RCC中caveolin-1阳性表达率为38.9%(37/95),survivin阳性表达率为69.5%(66/95)。局限性肾癌中caveolin-1和survivin蛋白表达之间呈负相关(rs=-0.665,P<0.05),在局部进展性和转移性肾癌中两者呈正相关(rs=0.563,P<0.05)。结论:Caveolin-1和survivin在RCC的发生和临床进展中均发挥重要作用,可望作为反映RCC发展变化有用的生物学标记,两者的联合检测对于判断RCC预后具有较大意义。
作者 任选义 魏金星 张雪培 李惠翔 王智勇 吕新全
机构地区 郑州大学第一附属医院泌尿外科 河南省开封市第一人民医院 郑州大学第一附属医院病理科
出处 《实用医学杂志》 CAS 北大核心 2011年第20期3681-3683,共3页 The Journal of Practical Medicine
关键词 肾肿瘤 免疫组织化学 CAVEOLIN-1 SURVIVIN
分类号 R737.11 [医药卫生—肿瘤]
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参考文献9

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共引文献2

同被引文献8

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实用医学杂志
2011年 第20期

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