新诊断2型糖尿病患者血浆内脂素及FFA水平的变化

Change of plasma visfatin and free fatty acids levels in patients with newly diagnosed type 2 diabetes mellitus

目的:探讨新诊断2型糖尿病患者血浆内脂素及游离脂肪酸水平的变化。方法:检测106例T2DM患者(T2DM组)和100例健康体检者(对照组)血浆内脂素、FFA和相关临床指标。结果:T2DM患者血浆内脂素、FFA水平高于正常对照组(P<0.01)。多元线性逐步回归分析显示腰臀比和空腹血糖是影响血浆内脂素水平的独立相关因素。结论:血浆内脂素水平变化与糖脂代谢关系密切,它可能在T2DM的发病机制中起着一定作用。

Objective To investigate the change of plasma visfatin and free fatty acids （FFA） levels in patients with newly diagnosed type 2 diabetes mellitus （T2DM）. Methods Plasma visfatin and FFA concentrations and clinical indicators were measured in 106 patients with newly diagnosed T2DM （T2DM group） and 100 normal control subjects （control group）. Results Plasma visfatin and FFA levels in T2DM group were higher than those in control group （P 〈 0.01 ）. Multi-dimensional linear stepwise regression analysis showed waist to hip ratio（WHR） and fasting blood glucose （FBG） were independent associated factors which affected plasma visfatin level. Conclusions The change of plasma visfatin level is associated closely with metabolism of glucose and lipid, that may plays a role in the pathogenesis of T2DM.