结缔组织病肺间质疾病临床及高分辨CT特点分析

The Analysis of Clinical and High Resolution CT Characteristics of Connective Tissue Disease-Related Interstitial Lung Diseases

目的:通过对不同种类结缔组织病(CTD)肺间质疾病(ILD)的临床及高分辨CT(HTCT)影像表现进行总结分析,研究其临床及HTCT影像特点,判断病情及预后。方法:回顾性分析53例不同CTD-ILD的临床及高分辨CT(HRCT)表现,总结不同CTD-ILD的临床表现及影像表现特点:相关数据进行统计学处理,研究其可能的相关性。结果:53例CTD-ILD的临床表现,咳嗽/干咳占56.6%;胸闷/气短占43.4%;呼吸困难39.6%;胸痛37.7%;爆裂音81.1%;pSS-ILD干咳发生率明显高于其它组(P﹤0.05);SSc-ILD呼吸困难发生率明显高于其它组(P﹤0.05)。HRCT影像表现特点:磨玻璃影50.9%;网格影28.3%,蜂窝影26.4%,实变影17.0%,结节影9.4%。RA-ILD、pSS-ILD磨玻璃影发生率明显高于其它组(P﹤0.05),SSc-ILD的网格影、蜂窝影发生率明显高于其它组(P﹤0.05)。结论:不同CTD-ILD临床和影像表现具有特征性,部分临床表现与影像表现之间具有一定的相关性。

Objective： To study the clinical and imaging features of HTCT and determine the condition and prognosis of different types of connective tissue disease（CTD） interstitial lung disease（ILD）. Method： Retrospective analysed 53 patients with CTD-ILD in different clinical and high-resolution CT（HRCT） performance,summarized the different clinical manifestation of CTD-ILD and imaging performance characteristics,the data were analyzed statistically to study the possible correlation. Result： 53 patients with CTD-ILD of clinical manifestations：cough / dry cough was 56.6%;chest tightness/shortness of breath was 43.4%;dyspnea was 39.6%;chest pain was 37.7%;crackles was 81.1%;pSS-ILD dry cough was significantly higher than the other groups（P〈0.05）;SSc-ILD dyspnea were significantly higher than the other groups（P〈0.05）.HRCT images show features： ground glass opacity was 50.9%;reticular change was 28.3%,honeycomb change was 26.4%,consolidation was 17.0%,nodules was 9.4%.RA-ILD 、pSS-ILD ground glass were significantly higher than other groups（P〈0.05）,SSc-ILD grid shadow,honeycombing were significantly higher than the other groups（P〈0.05）. Conclusion：Different CTD-ILD in clinical and imaging findings with characteristic,Part of the clinical manifestations and imaging performance have some correlation.