血管内皮生长因子在乳腺癌中的表达及临床意义

The expression of vascular endothelial growth factor and clinical significance in breast cancer

目的研究血管内皮生长因子（VEGF）在乳腺癌中的表达及临床意义。方法应用S-P免疫组化方法检测60例乳腺癌组织（乳腺癌组）和20例乳腺良性病变组织（乳腺纤维腺瘤组）中VEGF的表达情况，结合临床及病理形态学资料进行统计分析。结果乳腺癌组中VEGF阳性表达49例；乳腺纤维腺瘤组中VEGF阳性表达4例；2组VEGF阳性率比较差异有统计学意义（81．67％与20．00％，u=4．39，P=0．000）。VEGF的表达与淋巴结转移、肿瘤大小、组织学分级和临床分期呈正相关（rs=0．357、0．594、0．680、0．540，P均〈0．05），与患者年龄、雌激素、孕激素受体情况无相关性（P均〉0．05）。结论VEGF可能与乳腺癌的进展、转移及预后有关，作为独立的指标对判定预后具有参考意义。

Objective To study the expression of vascular endothelial growth factor（VEGF） in breast cancer and its clinical significance. Methods The expression of the protein was determined by immunohistochemistry in 60 cases of breast cancer and 20 cases of benign breast diseases The relationship of VEGF expression with clinicopathological characteristics was statistically analyzed. Results Of all the 60 cases of breast cancers,49 cases showed positive VEGF expression,while only 4 cases expressed VEGF in the group of breast adenofibroma. There was significant difference between breast cancer and breast adenofibroma（P 〈 0. 05 ） The overexpression of VEGF was related with the tumor size （ P 〈 0. 05 ）, histological grade （ P 〈 0. 05 ）, lymph node state（P 〈0. 05） and TNM stage（P 〈0. 05） ,but was irrelevant to age,ER and PR（P 〉0. 05）. Conclusion VEGF might have important significance in the development, metastasis and prognosis of human breast cancer. It may be taken as an independent marker to predict the prognosis of breast cancer.