摘要
目的探讨血管内皮生长因子(VEGF)和核转录因子κB(NF-κB)的表达与前列腺癌生物学行为的关系。方法应用免疫组织化学方法检测40例前列腺增生组织(前列腺增生组)、53例前列腺癌组织(前列腺癌组)中VEGF和NF-κB的表达。结果前列腺癌组NF-κB和VEGF阳性表达率分别为64.2%,69.8%,均高于前列腺增生组12.5%,37.5%(χ2=24.976、9.655,P均〈0.01);NF-κB和VEGF的表达随着肿瘤分化程度的降低和临床分期的增加,呈现逐渐升高的趋势,差异均有统计学意义(χ2=15.936、18.459、4.316、14.205,P〈0.01或P〈0.05);VEGF与NF-κB的表达呈正相关(r=0.297,P=0.027)。结论前列腺癌组织中VEGF与NF-κB表达明显相关,可以利用VEGF和NF-κB来判定前列腺癌的生物学行为。
Objective To explore the relationship between the expression of NF-KB and VEGF and the biological behaviors of prostatic carcinoma. Methods Immunohistochemical method was used to examine the expression of NF-KB and VEGF in 40 eases of benign prostatic hyperplasia(BPH) and 53 cases of prostatic carcinoma. Results The positive rates of NF-KB and VEGF in prostatic carcinoma and BPH were 64. 2% and 69. 8% ,12. 5% and 37. 5% respectively. There are more cases with positive NF-KB and VEGF expression in prostatic carcinoma group than in the BPH group( χ2 = 24.976,9.655 ,P 〈 0. 01 ). The expression of VEGF and NF-KB in prostatic carcinomas increased significantly with the decrease of tumor differentiation and advance of the TNM stages ( χ2 = 15. 936,18.459 ; 4. 316, 14. 205, P 〈 0. 01 or P 〈 0.05 ) ; The expression of VEGF in prostatic carcinoma was positively correlated with NF-KB ( r = 0. 297, P = 0. 027 ). Conclusion The expression of VEGF and NF-KB in prostatic carcinoma are highly correlated with each other and may be suggestive to understand the biological behavior of prostatic carcinoma.
出处
《中国综合临床》
2011年第10期1080-1082,共3页
Clinical Medicine of China
关键词
前列腺肿瘤
血管内皮生长因子
核转录因子ΚB
免疫组织化学
Prostatic neoplasms
Vascular endothelial growth factors
Nuclear factor of kappa B
Immunohistochemistry