核转录因子κB与血管内皮生长因子在前列腺癌组织的表达及意义

Expression and significance of NF-κB and VEGF in the prostatic cancer

目的探讨血管内皮生长因子（VEGF）和核转录因子κB（NF-κB）的表达与前列腺癌生物学行为的关系。方法应用免疫组织化学方法检测40例前列腺增生组织（前列腺增生组）、53例前列腺癌组织（前列腺癌组）中VEGF和NF-κB的表达。结果前列腺癌组NF-κB和VEGF阳性表达率分别为64．2％，69．8％，均高于前列腺增生组12．5％，37．5％（χ2=24．976、9．655，P均〈0．01）；NF-κB和VEGF的表达随着肿瘤分化程度的降低和临床分期的增加，呈现逐渐升高的趋势，差异均有统计学意义（χ2=15．936、18．459、4．316、14．205，P〈0．01或P〈0．05）；VEGF与NF-κB的表达呈正相关（r=0．297，P=0．027）。结论前列腺癌组织中VEGF与NF-κB表达明显相关，可以利用VEGF和NF-κB来判定前列腺癌的生物学行为。

Objective To explore the relationship between the expression of NF-KB and VEGF and the biological behaviors of prostatic carcinoma. Methods Immunohistochemical method was used to examine the expression of NF-KB and VEGF in 40 eases of benign prostatic hyperplasia（BPH） and 53 cases of prostatic carcinoma. Results The positive rates of NF-KB and VEGF in prostatic carcinoma and BPH were 64. 2% and 69. 8% ,12. 5% and 37. 5% respectively. There are more cases with positive NF-KB and VEGF expression in prostatic carcinoma group than in the BPH group（ χ2 = 24.976,9.655 ,P 〈 0. 01 ）. The expression of VEGF and NF-KB in prostatic carcinomas increased significantly with the decrease of tumor differentiation and advance of the TNM stages （ χ2 = 15. 936,18.459 ; 4. 316, 14. 205, P 〈 0. 01 or P 〈 0.05 ） ; The expression of VEGF in prostatic carcinoma was positively correlated with NF-KB （ r = 0. 297, P = 0. 027 ）. Conclusion The expression of VEGF and NF-KB in prostatic carcinoma are highly correlated with each other and may be suggestive to understand the biological behavior of prostatic carcinoma.