5-羟色胺与焦虑、抑郁的关系及其在溃疡性结肠炎发病中的作用

The role of 5-HT,anxiety and depression in ulcerative colitis

目的研究溃疡性结肠炎患者5-羟色胺与焦虑、抑郁评分的关系,进一步探讨神经肽及焦虑、抑郁因素在溃疡性结肠炎中的作用。方法收集UC病例(42例)、IBS病例(20例)及正常对照(10例)的结肠镜活检标本。采用汉密顿抑郁量表(HAMD)和汉密顿焦虑量表(HAMA)对所有受试者进行焦虑抑郁评分;应用高效液相色谱法检测肠黏膜中5-羟色胺的含量。结果 UC患者存在明显的焦虑、抑郁症状,中重度UC患者结肠黏膜中5-HT的含量均较正常对照组增高,尤其重度UC增高明显,UC患者焦虑、抑郁评分与肠黏膜5-HT含量呈正相关,并在一定程度上反映临床轻重程度分级。结论 UC存在神经内分泌的改变,且神经激素的改变可能参与UC疾病进展。

Objective To study the relationship of 5-HT and anxiety,depression score in patients with ulcerative colitis,and further explore the role of neuropeptides,anxiety and depression factors in ulcerative colitis.Methods UC patients（42 cases）,IBS patients（20 cases） and normal controls（10 cases） were collected by Hamilton Depression Rating Scale（HAMD） and Hamilton Anxiety Scale（HAMA） of all subjects to anxiety and depression rating;high-performance liquid chromatography was used to detect 5-hydroxytryptamine content in intestinal mucosa.Results UC patients had significant anxiety,depression.5-HT levels of colonic mucosa in moderate and severe UC were higher than those in normal control group.In particular,severe UC increased significantly.In UC patients,anxiety and depression score were positive correlation with 5-HT content of intestinal mucosa,they reflected the clinical severity classification.Conclusion UC presence of neuroendocrine changes and neurohormonal changes in UC progression may be involved.