Toll样受体-4及其介导的信号转导与急性前葡萄膜炎

Toll like receptor 4 and its mediated signal transduction with acute anterior uveitis

急性前葡萄膜炎是最常见的葡萄膜炎,其发病机制尚不明确。近年来研究认为,G阴性细菌感染启动、Toll样受体-4介导的信号转导在急性前葡萄膜炎的发病机制中发挥重要作用。本文对目前脂多糖-Toll样受体-4信号转导通路及通过对该通路干预来调控炎症的相关研究进展进行综述,以期为前葡萄膜炎的治疗提供新的思路。

Acute anterior uveitis,which pathogenesis is still not explicit,is the most common uveitis.Recent years,some researchers believe that Gram-negative bacterium infection initiating,toll like receptor 4 signal transduction may play an important role in the pathogenesis of acute anterior uveitis.In this article,we review the present lipopolysaccharide-Toll like receptor 4 pathways and intervention for the way,in the hope of supplying some new ideas for the treatment of acute anterior uveitis.