CEA与CA15-3联合检测在乳腺癌诊断中的临床意义

Application of combined detection of CEA and CA15-3 in the serum from patients with breast cancer

目的:探讨癌胚抗原(carcinoembryo antigen,CEA)与肿瘤相关糖类抗原15-3(carbohydrate antigen15-3,CA15-3)联合检测在乳腺癌诊断中的应用价值。方法:采用电化学发光方法检测116例乳腺癌患者与94例乳腺良性肿瘤患者血清中CEA与CA15-3水平并进行统计学分析。结果:乳腺癌患者血清中CEA与CA15-3水平明显高于乳腺良性肿瘤对照组(P<0.01);二者联合检测诊断敏感性显著提高(P<0.05);治疗后CEA与CA15-3含量与治疗前相比显著无明显变化(P>0.05)。结论:CEA与CA15-3联合检测可提高乳腺癌诊断敏感性,对临床诊断与疗效评价有一定的应用价值。

Objective：To investigate the diagnostic value of detection of CEA and CA15-3 in serum of patients with breast cancer.Methods： Serum levels of CEA and CA15-3 were measured by electrochemiluminescence assay in 116 breast cancer patients and 94 patients with benign breast tumor.Results： The levels of CEA and CA15-3 in patients with breast cancer were obviously higher than those in control group with benign tumor（P0.01）,sensitivity of combined detection was significantly increased（P0.05）.Conclusion： Combined detection of CEA and CA15-3 has a notable value in clinical diagnosis and therapeutic evaluation for breast cancer patients.