奈达铂腔内灌注联合热疗治疗肺癌胸腔积液的临床观察

A clinical study of thoracic cavity perfusion with nedaplatin combined with chemotherapy for pleural effusion with lung cancer

目的:观察奈达铂胸腔灌注联合热疗治疗肺癌胸腔积液的疗效、生活质量和不良反应。方法:确诊为肺癌恶性胸腔积液的患者50例,随机分成两组,采用中心静脉导管胸腔闭式引流排尽胸水后,A组(26例)给予胸腔灌注奈达铂化疗,随后进行患侧胸腔深部热疗;B组(24例)只给予胸腔灌注奈达铂化疗。结果:A组控制胸水的有效率为88.4%,B组为62.5%(P<0.05);A组与B组的生活质量好转率分别为84.6%和50.0%(P<0.05)。结论:采用热疗联合奈达铂胸腔灌注治疗肺癌恶性胸腔积液疗效确切,不良反应小,安全性高。

Objective：To investigate the efficacy,quality of life and side effects of thermotherapy joint with nedaplatin pleural reperfusion lung cancer pleural effusion.Methods： Patients diagnosed with lung cancer with malignant pleural effusion 50 cases were randomly divided into two groups.The treatment group（26 cases） were treated with nedaplatin into thoracic cavity and received concurrent hyperthemia.The control group（24 cases） were treated with nedaplatin alone.Results： The response rates of treatment group were 88.4%,and 62.5% for the control group（P0.05）.The treatment group and control group＇s quality of life improvement rates were 84.6% and respectively（P0.05）.Conclusion： The heat treatment to joint Nedaplatin pleural reperfusion malignant pleural effusion of lung cancer has definite effect and adverse reaction is small.