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炎性体复合物及其与脓毒症的关系研究进展

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摘要 自2002年Martinon等[1]发现炎性体复合物（inflammasome）以来,人们对它们的结构和功能及其诱导机制的认识在不断完善。炎性体复合物通过控制半胱天冬氨酸酶1（caspase-1）的活化进而调节着机体的炎症反应,并在抗感染过程中发挥着积极的保护作用。脓毒症是感染引起的全身炎症反应,炎性体复合物可能参与了脓毒症炎症反应的启动和抗感染过程。
作者 刘召军 刘嘉琳 瞿洪平
机构地区 上海交通大学医学院附属瑞金医院RICU
出处 《中国呼吸与危重监护杂志》 CAS 2011年第5期509-512,共4页 Chinese Journal of Respiratory and Critical Care Medicine
关键词 复合物 脓毒症 炎性 全身炎症反应 感染过程 诱导机制 保护作用
分类号 R459.7 [医药卫生—急诊医学]
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参考文献25

  • 1Martinon F,Burns K,Tschopp J. The inflammasome:a molecular platform triggering activation of inflammatory caspases and processing of prolL-beta. Mol Cell,2002,10:417-426.
  • 2Fahy RJ,Exline MC,Gavrilin MA,et al. Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med,2008,177:983-988.
  • 3Giamarellos-Bourboulis EJ,van de Veerdonk FL,Mouktaroudi M,et al. Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia. Crit Care,2011,15:R27.
  • 4Ferwerda G,Kramer M,de Jong D,et al. Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1 beta. Eur J Immunol,2008,38:184-191.
  • 5Stutz A,Golenbock DT,Latz E. Inflammasomes:too big to miss. J Clin Invest,2009,119:3502-3511.
  • 6Hsu LC,Ali SR,McGillivray S,et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci USA,2008,105:7803-7808.
  • 7Martinon F,Tschopp J. Inflammatory caspases and inflammasomes:master switches of inflammation. Cell Death Differ,2007,14:10-22.
  • 8Manji GA,Wang L,Geddes BJ,et al. PYPAF1,a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. J Biol Chem,2002,277:11570-11575.
  • 9van de Veerdonk FL,Netea MG,Dinarello CA,et al. Inflammasome activation and IL-1beta and IL-18 processing during infection. Trends Immunol,2011,32:110-116.
  • 10Geddes BJ,Wang L,Huang WJ,et al. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem Biophys Res Commun,2001,284:77-82.

二级参考文献6

  • 1The Acute Respiratory Distress Syndrome Network : Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med ,2000,342 : 1301-1308.
  • 2Ferguson ND, Frutos-Vivar F, Esteban A, et al. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med ,2005,33:21-30.
  • 3Villar J, Kacmarek RM, Perez-Mendez L, et al. A high positive endexpiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome : A randomized, controlled triM. Crit Care Med ,2006 ,34 : 1311-1318.
  • 4van den Berg PC, Jansen JR, Pinsky MR. Effect of positive pressure on venous return in volume-loaded cardiac surgical patients. J Appl Physiol,2002,92 : 1223-1231.
  • 5George DL, Falk PS, Wunderink RG, et al. Epidemiology of ventilator acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med, 1998,158 : 1839-1847.
  • 6Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl, 2004,10:817-827.

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中国呼吸与危重监护杂志
2011年 第5期

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