HIF-2α和OCT-4在非小细胞肺癌中的表达及与预后的关系

Correlation between expression of HIF-2α and OCT-4 and prognosis of NSCLC

目的:通过联合检测缺氧诱导因子-2α(HIF-2α)和转录因子OCT-4在非小细胞肺癌(NSCLC)中的表达,分析两者的相关性及其对NSCLC预后的影响。方法:应用免疫组织化学SP法检测51例NSCLC术后石蜡切片中HIF-2α和OCT-4蛋白的表达,分析两者的相关性及其与NSCLC临床预后的关系。结果:NSCLC组织中HIF-2α表达阳性率为52.9%,OCT-4阳性率为72.5%,两者在NSCLC组织中的表达呈正相关(r=0.514,P<0.01)。HIF-2α和OCT-4的表达均与病人的生存时间相关,阳性表达的NSCLC患者预后差。结论:HIF-2α和OCT-4在NSCLC中的高表达与NSCLC预后不良相关,两者可作为NSCLC预后判断的指标。

Objective To investigate the expression and significance of hypoxia inducible factor-2a （HIF-2a） and transcription factor OCT-4 in non-small cell lung cancer （NSCLC）, and evaluate their roles in the prognosis of NSCLC. Methods Tissues from 51 cases of NSCLC were col- lected and immunohistochemistry （SP method） was used to detect the expression of HIF-2a and OCT-4 proteins. The correlation between the protein expression and the prognosis of NSCLC was an- alyzed. Results The positive rates of HIF-2a and OCT-4 expression in the NSCLC were 52.9% and 72.5%, respectively. There was significant relation between the expression of HIF-2ct and OCT-4 （r = 0. 514,P 〈 0.01 ）. High expression of them revealed poor prognosis for NSCLC patients characterized with a bad overall survival （ P 〈 0.05 ）. Conclusion There is a negative corelation between the expression of HIF-2ct and OCT-4 and the prognosis of NSCLC. Combined examination of HIF-2ct and OCT-4 expression might be an important biomarker for NSCLC prognosis.