石杉碱甲对不同严重程度血管性痴呆患者的疗效分析

Evaluate the Therapeutic Efficacy of Huperzine A on the Different Degree of Vascular Dementia Patients in Different Dose

目的:分析不同剂量石杉碱甲对不同严重程度血管性痴呆(VaD)的长期疗效。方法:纳入255例VaD患者,按痴呆程度不同分层。其中180例入组石杉碱甲组,随机给予不同剂量石杉碱甲(高剂量组:0.15mg;低剂量组:0.05mg);75例设为吡拉西坦(0.4g)为对照组,均连续用药52周。分别在0、12及52周末进行简易精神状态量表(MMSE)和日常生活能力(ADL)量表进行评定。结果:不同严重度VaD患者石杉碱甲高剂量组在治疗12周后MMSE、ADL评分改善最明显(P<0.05)。轻度VaD患者石杉碱甲高剂量组在治疗12周后MMSE、ADL评分改善疗效最好。结论:不同剂量石杉碱甲对VaD的疗效与剂量呈正相关,VaD患者的认知功能呈进行性下降,高剂量石杉碱甲能延缓VaD患者的认知功能下降。

Aim：To evaluate the therapeutic efficacy of Huperzine A on the different degree of vascular dementia patients in different dose.Methods：255 patients with different degree of vascular dementia were randomly divided into three groups.Patients in group1-2 were given Huperzine A in different dose for 52 weeks,while patients in the control group were given piracetam.Mini-Mental Status Examination（MMSE） and Activities of Daily Living（ADL） were evaluated and compared between the pre-programand,post-12-week-programand and post-52-week-programed.Results：After 52-weeks of Huperzine A in different degree of vascular dementia,the scores of MMSE and ADL in different groups of high doses were improved significantly（P0.05）.Compared with other groups,the scores of MMSE and ADL of patients of mild vascular dementia in different groups of high doses were improved significantly.Conclusion：Therapeutic efficacy of Huperzine A on the vascular dementia patients is positive correlated with the dose.High doses of Huperzine A can decrease the progression in patients with vascular dementia.