PARP-1基因Val762Ala多态性与乳腺癌易感性的关系

Relation between PARP-1 Val762Ala Polymorphisms and Susceptibility to Breast Cancer

目的探讨DNA修复基因聚腺苷二磷酸核糖聚合酶-1(PARP-1)单核苷酸多态性位点Val762Ala基因多态性与中国人群乳腺癌易感性的关系。方法采用Sequenom MassARRAY单核苷酸多态性(SNP)基因型分析技术对经病理确诊的原发性乳腺癌女性患者837例(病例组)和健康对照组865例进行PARP-1基因单核苷酸位点Val762Ala基因分型。以非条件logistic回归计算优势比(odds ratio,OR)及其95%可信区间(CI)评价各基因型与乳腺癌发病风险的关系。数据均由SPSS13.0统计软件分析。结果病例组和对照组中TT、TC、CC和TC+CC 4种基因型的分布分别差异无统计学意义,OR[95%CI]值分别为1、1.07(0.83～1.39)、1.03(0.70～1.36)、1.08(0.82～1.33)。结论 Val762Ala基因型与乳腺癌易感性无显著相关性。PARP-1基因Val762Ala多态性在乳腺癌发病过程中无作用。

[Objective] To investigate the association between the Val762Ala polymorphisms of the poly（ADP-ribose） polymerase-1（PARP-1） gene and susceptibility to breast cancer in a Chinese population. [Methods]PARP-1 Val762Ala genotyping were conducted in 837 breast carcinoma patients and 865 cancer-free controls by Sequenom MassARRAY（SNP） genotype analysis technique.The associations between genotypes and breast cancer risk were estimated by computing the ORs and their 95% CIs from non-conditional logistic regression analyses.Experiment data was analyzed by using SPSS13.0 software. [Results]The differences of genotype TT,TC,CCand TC＋CC distributions between patients and controls were not significant,OR[95% CI] values were 1,1.07（0.83~1.39）,1.03（0.70~1.467,1.08（0.82~1.33）. [Conclusion]Val762Ala is not obviously correlated with susceptibility to breast cancer.tThe PARP-1 Val762Ala polymorphisms may not play a role in the etiology of breast cancer.