血清胱抑素C检测对2型糖尿病肾损害的价值

Value of Detection of Serum Cystatin C for Renal Damage in Type 2 Diabetes Mellitus

目的检测血清胱抑素C(Cys C)浓度并与血清肌酐(SCr)相比较,从而探讨Cys C检测在2型糖尿病中的临床意义。方法 2型糖尿病组123例,健康对照组104例,分别测定血清Cys C和SCr浓度,并对2组数据的结果进行比较分析。结果糖尿病组中Cys C、SCr水平明显高于健康对照组(P<0.01;P<0.05);糖尿病组中Cys C阳性率为65.85%,明显高于SCr阳性率(26.83%;P<0.01);CysC与SCr均呈明显正相关(r=0.563)。结论血清Cys C在2型糖尿病中有较高的检出率,可作为反映2型糖尿病患者早期肾损害的良好指标。

[Objective]To test and compare the levels of serum cystatin C（Cys C） and serum creatinine（Scr）,study the clinical significance of Cys C detection for type 2 diabetes mellitus. [Methods]The levels of Cys C and Scr were detected in the type 2 diabetes mellitus group（123 cases） and healthy control group（104 cases）,and the results of two groups were compared. [Results]The levels of Cys C and Scr of the type 2 diabetes mellitus group were significantly higher than that of the healthy control group（P0.01;P0.05）.In the type 2 diabetes mellitus group,the positive rate of Cys C（65.85%） was higher than that of Scr（26.83%） significantly（P0.01）.There was a significant positive correlation between Cys C and Scr（r=0.563）. [Conclusion]The detection rate of Cys C is high in patients with type 2 diabetes mellitus group,and it can be used as a good serological indicator for early renal damage in type 2 diabetes mellitus.