摘要
脂肪乳作为一种给药载体,不论处方组成还是制备工艺已经日益成熟。SolEmul技术给油水均难溶药物的制剂带来希望;自乳化给药系统可提高难溶性药物的生物利用度;阳离子脂肪乳不仅延长药物体内循环时间,还使肺部给药技术得到长足发展;同时脂肪乳在细胞靶向和中药制剂的研究中也呈现出独特的优势。随着载药脂肪乳各项研究的深入和发展,未来应用范围必将更加广泛。
As a drug carrier, lipid emulsion has become increasingly mature regardless the prescription composition or preparation methods. SolEmul technology brings hope to insoluble drugs in oil and water; self-emulsifying drug delivery system can improve the bioavailability of the insoluble drugs; cationic lipid emulsion not only extends the drug circulation time, but also greatly develops the pulmonary drug delivery technology; while lipid emulsion has also shown a distinct advantage in cell targeting studies and Chinese medicine formulations. As the drug-loaded lipid emulsion is in-depth study and development, the future will be having more wide range of applications.
出处
《现代药物与临床》
CAS
2011年第5期339-343,共5页
Drugs & Clinic
基金
国家重点基础研究发展计划项目(2010CB735602)
天津市科技支撑项目(09ZCKFSH01200)
关键词
载药脂肪乳
乳化剂
制备方法
脂肪乳剂
drug-loaded lipid emulsion
emulsifier
preparation methods
lipid emulsions
