尿激酶配合氢溴酸山莨菪碱股动脉溶栓对糖尿病足的疗效观察

Effective observation of urokinase combined with anisodamine hydrobromide treatment on diabetic foot by intra-arterial thrombolysis

目的观察股动脉溶栓治疗糖尿病足的临床疗效。方法将40例糖尿病足患者随机分为治疗组和对照组，每组20例，治疗组忠侧股动脉穿刺并滴注尿激酶（2．5×10＾5U）配合氢溴酸山莨菪碱（10mg）溶栓，对照组静脉滴注前列腺素E。注射液（10gg）。结果治疗组糖尿病足的有效率95％，对照组的有效率80％，两组比较差异有显著性（P〈0．05）。足背动脉多普勒检查显示，治疗组治疗后血流速度改善显著优于对照组（P〈0．05）。结论动脉内溶栓治疗糖尿病足具有操作简便、治疗时间短、址效快以及治疗费用低的特点，容易被老年患者接受，可以在老年病医院推广。

Objective To investigate the clinical experience of diabetic foot （DF） by intra-femoral artery thrombolysis. Methods Forty patients with DF were randomly divided into two groups. The treatment group （20 cases） were puncturing femoral artery in the lesion side of lower-extremity to drip urokinase thrombolysis （2.5 × l 05 U） combined with anisodamine hydrobromide （10 mg）, the control group （20 cases） were injected PGE1 Injection by vein. Results The effective rate of DF was 95% in the treatment group and 80% in the control group, the difference between the two groups was significant （P〈0.05）. The Doppler of arteria dorsalis pedis showed that the improvement of blood flow rate in the treatment group was significantly outweigh that in the control group （P〈0.05）. Conclusion Treating DF by intra-arterial thrombolysis is easy to be accepted for these advantages： short cure time, fast effect, and low cost, so this therapy could be widely used in geriatrics hospital.